Antiprotozoal Constituents from Annona cherimola Miller, a Plant Used in Mexican Traditional Medicine for the Treatment of Diarrhea and Dysentery.

ABSTRACT:

Background

Annona cherimola Miller (Annonaceae) is a medicinal plant frequently recommended in Mexican traditional medicine for the treatment of gastrointestinal disorders such as diarrhea and dysentery.

Objective

This work was undertaken to obtain information that support the traditional use of A. cherimola, on pharmacological basis using in vitro and computational experiments.

Material and methods

Bioassay-guided fractionation of the ethanol extract of the leaves of A. cherimola afforded five phenolic compounds: caffeic acid, quercetin, kaempferol, nicotinflorin, and rutin.

Results

The in vitro antiprotozoal assay showed that kaempferol was the most potent antiamoebic and antigiardial compound with IC₅₀ values of

SUBMITTER: Calzada F 

PROVIDER: S-EPMC5307900 | biostudies-literature | 2017 Jan-Mar

REPOSITORIES: biostudies-literature