Effect of 15-Deoxy-Δ^12,14-prostaglandin J₂Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model.

ABSTRACT:

Background

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), one of the major metabolites from prostaglandin D2 in arachidonic acid metabolic pathway, has potential anti-inflammatory properties. The objective of this study was to explore the effects of 15d-PGJ2-loaded poly(D,L-lactide-co-glycolide) nanocapsules (15d-PGJ2-NC) on inflammatory responses and bone regeneration in local bone defect.

Methods

The study was conducted on 96 Wistar rats from June 2014 to March 2016. Saline, unloaded nanoparticles, free 15d-PGJ2or 15d-PGJ2-NC, were delivered through a collagen vehicle inside surgically created transcortical defects in rat femurs. Interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) levels in the surrounding soft tissue were analyzed by We

SUBMITTER: Tang Q 

PROVIDER: S-EPMC5308019 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature