The Relationship between NMR Chemical Shifts of Thermally Polarized and Hyperpolarized ⁸⁹ Y Complexes and Their Solution Structures.

ABSTRACT: Recently developed dynamic nuclear polarization (DNP) technology offers the potential of increasing the NMR sensitivity of even rare nuclei for biological imaging applications. Hyperpolarized ⁸⁹ Y is an ideal candidate because of its narrow NMR linewidth, favorable spin quantum number (I=1/2 ), and long longitudinal relaxation times (T₁ ). Strong NMR signals were detected in hyperpolarized ⁸⁹ Y samples of a variety of yttrium complexes. A dataset of ⁸⁹ Y NMR data composed of 23 complexes with polyaminocarboxylate ligands was obtained using hyperpolarized ⁸⁹ Y measurements or ¹ H,⁸⁹ Y-HMQC spectroscopy. These data were used to derive an empirical equation that describes the correlation between the ⁸⁹ Y c

SUBMITTER: Xing Y 

PROVIDER: S-EPMC5308128 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature