Association of prenatal and childhood PBDE exposure with timing of puberty in boys and girls.

ABSTRACT:

Background

Polybrominated diphenyl ether (PBDE) flame retardants are endocrine-disrupting chemicals that exhibit estrogenic and androgenic properties and may affect pubertal timing.

Methods

Study subjects were participants between 1999 and 2013 in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a longitudinal cohort study of predominantly Mexican origin families in Northern California. We measured serum concentrations of four PBDEs (BDE-47, -99, -100, -153) in blood collected from mothers during pregnancy (N=263) and their children at age 9years (N=522). We determined timing of pubertal onset in 309 boys and 314 girls using clinical Tanner staging every 9months between 9 and 13years of age, and timing of menarche by self-report. We used Po

SUBMITTER: Harley KG 

PROVIDER: S-EPMC5308219 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature