Point process models for localization and interdependence of punctate cellular structures.

ABSTRACT: Accurate representations of cellular organization for multiple eukaryotic cell types are required for creating predictive models of dynamic cellular function. To this end, we have previously developed the CellOrganizer platform, an open source system for generative modeling of cellular components from microscopy images. CellOrganizer models capture the inherent heterogeneity in the spatial distribution, size, and quantity of different components among a cell population. Furthermore, CellOrganizer can generate quantitatively realistic synthetic images that reflect the underlying cell population. A current focus of the project is to model the complex, interdependent nature of organelle localization. We built upon previous work on developing multiple non-parametric models of organelles or str

SUBMITTER: Li Y 

PROVIDER: S-EPMC5308220 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature