The influence of biomechanical properties and cannabinoids on tumor invasion.

ABSTRACT:

Background

Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to distinguish between tumor cells and the healthy tissue. We tested the hypothesis whether cannabinoids influence the tumor cell specific mechanical and migratory properties and if these factors are a prognostic marker for the invasiveness of tumor cells.

Methods

3 different glioblastoma cell lines were treated with cannabinoids and changes of mechanical and migratory properties of single cells were measured using atomic force microscopy and time lapse imaging. The invasiveness of cell lines was determined using a co-culture model with organotypic hippocampal slice cultures.

R

SUBMITTER: Hohmann T 

PROVIDER: S-EPMC5308229 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature