Dual-emissive nanoarchitecture of lanthanide-complex-modified silica particles for in vivo ratiometric time-gated luminescence imaging of hypochlorous acid.

ABSTRACT: We have developed a ratiometric time-gated luminescence sensory system for in vivo imaging of hypochlorous acid (HClO) by preparing a dual-emissive nanoarchitecture of europium- and terbium-complex-modified silica nanoparticles. The design of this nanoarchitecture is based on our new finding that the strong, long-lived luminescence of the β-diketonate-Eu³⁺ complex can be rapidly and selectively quenched by HClO. Therefore, the β-diketonate-Eu³⁺ complex was decorated on the surface of the silica nanoparticles for responding to HClO, while a HClO-insensitive luminescent terbium complex was immobilized in the inner solid core of the nanoparticles to serve as an internal standard. This nanosensing probe combines the advantages of both ratiometric and time-gated det

SUBMITTER: Ma H 

PROVIDER: S-EPMC5308275 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature