A validated active contour method driven by parabolic arc model for detection and segmentation of mitochondria.

ABSTRACT: Recent studies reveal that mitochondria take substantial responsibility in cellular functions that are closely related to aging diseases caused by degeneration of neurons. These studies emphasize that the membrane and crista morphology of a mitochondrion should receive attention in order to investigate the link between mitochondrial function and its physical structure. Electron microscope tomography (EMT) allows analysis of the inner structures of mitochondria by providing highly detailed visual data from large volumes. Computerized segmentation of mitochondria with minimum manual effort is essential to accelerate the study of mitochondrial structure/function relationships. In this work, we improved and extended our previous attempts to detect and segment mitochondria from transmission ele

SUBMITTER: Tasel SF 

PROVIDER: S-EPMC5308287 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature