A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease.

ABSTRACT: Recurrent bacterial infections are a significant burden worldwide, and prior history of infection is often a significant risk factor for developing new infections. For urinary tract infection (UTI), a history of two or more episodes is an independent risk factor for acute infection. However, mechanistic knowledge of UTI pathogenesis has come almost exclusively from studies in naive mice. Here we show that, in mice, an initial Escherichia coli UTI, whether chronic or self-limiting, leaves a long-lasting molecular imprint on the bladder tissue that alters the pathophysiology of subsequent infections, affecting host susceptibility and disease outcome. In bladders of previously infected versus non-infected, antibiotic-treated mice, we found (1) an altered transcriptome and defects in cell matu

SUBMITTER: O'Brien VP 

PROVIDER: S-EPMC5308540 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature