Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146.

ABSTRACT:

Objective

TCF7L2 variant rs7903146 is associated with increased risk for type 2 diabetes. We investigated the effect of TCF7L2 variant rs7903146 and glucose tolerance on free fatty acid (FFA) metabolism.

Research design and methods

We recruited 120 individuals, half homozygous for the major CC allele and half homozygous for the minor TT allele at rs7903146; each underwent a 2-h, 75g oral glucose tolerance test (OGTT). Plasma glucose, insulin and free fatty acid concentrations were measured on blood collected before and during the OGTT.

Results

Total FFA concentrations and percent FA species during OGTT were not different in CC and TT carriers when males and females were considered together. However, monounsaturated fatty acid (MUFA) concentrations and percentages were

SUBMITTER: Lu J 

PROVIDER: S-EPMC5308561 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature