Two SNPs in the promoter region of Toll-like receptor 4 gene are not associated with smoking in Saudi Arabia.
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ABSTRACT:
SUBMITTER: Kohailan M
PROVIDER: S-EPMC5308598 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Two SNPs in the promoter region of Toll-like receptor 4 gene are not associated with smoking in Saudi Arabia.
Kohailan Muhammad M Alanazi Mohammad M Rouabhia Mahmoud M Al Amri Abdullah A Parine Narasimha Reddy NR Semlali Abdelhabib A
OncoTargets and therapy 20170209
Defects in the innate immune system, particularly in Toll-like receptors (TLRs), have been reported in several cigarette smoke-promoted diseases. The aim of this study was to examine the impact of tobacco smoke on allelic frequencies of TLR4 single-nucleotide polymorphisms (SNPs) and to compare the genotypic distribution of these SNPs in a Saudi Arabian population with that in previously studied populations. DNA was extracted from 303 saliva samples collected from smokers and nonsmokers. Two tra ...[more]
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