Identification and functional analysis of long non-coding RNAs in human and mouse early embryos based on single-cell transcriptome data.

ABSTRACT: Epigenetics regulations have an important role in fertilization and proper embryonic development, and several human diseases are associated with epigenetic modification disorders, such as Rett syndrome, Beckwith-Wiedemann syndrome and Angelman syndrome. However, the dynamics and functions of long non-coding RNAs (lncRNAs), one type of epigenetic regulators, in human pre-implantation development have not yet been demonstrated. In this study, a comprehensive analysis of human and mouse early-stage embryonic lncRNAs was performed based on public single-cell RNA sequencing data. Expression profile analysis revealed that lncRNAs are expressed in a developmental stage-specific manner during human early-stage embryonic development, whereas a more temporal-specific expression pattern was identifie

SUBMITTER: Qiu JJ 

PROVIDER: S-EPMC5308646 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature