The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation.

ABSTRACT: Septins are a novel class of GTP-binding cytoskeletal proteins evolutionarily conserved from yeast to mammals and have now been found to play a contributing role in a broad range of tumor types. However, their functional importance in breast cancer remains largely unclear. Here, we demonstrated that pharmaceutical inhibition of global septin dynamics would greatly suppress proliferation, migration and invasiveness in breast cancer cell lines. We then examined the expression and subcellular distribution of the selected septins SEPT2 and SEPT7 in breast cancer cells, revealing a rather variable localization of the two proteins with cell cycle progression. To determine the role of both septins in mediating malignant behavior of cancer cells, we used RNA silencing to specifically deplete endog

SUBMITTER: Zhang N 

PROVIDER: S-EPMC5308674 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature