A polycomb-mediated epigenetic field defect precedes invasive cervical carcinoma.

ABSTRACT: Human papillomavirus (HPV)-associated cervical carcinoma is preceded by stages of cervical intra-epithelial neoplasia (CIN) that can variably progress to malignancy. Understanding the different molecular processes involved in the progression of pre-malignant CIN is critical to the development of improved predictive and interventional capabilities. We tested the role of regulators of transcription in both the development and the progression of HPV-associated CIN, performing the most comprehensive genomic survey to date of DNA methylation in HPV-associated cervical neoplasia, testing ~2 million loci throughout the human genome in biopsies from 78 HPV+ women, identifying changes starting in early CIN and maintained through carcinogenesis. We identified loci at which DNA methylation is consist

SUBMITTER: Wijetunga NA 

PROVIDER: S-EPMC5308716 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature