Optimization of the tumor microenvironment and nanomedicine properties simultaneously to improve tumor therapy.

ABSTRACT: Effective delivery of nanomedicines to tumor tissues depends on both the tumor microenvironment and nanomedicine properties. Accordingly, tumor microenvironment modification or advanced design of nanomedicine was emerging to improve nanomedicine delivery to tumors. However, few studies have emphasized the necessity to optimize the tumor microenvironment and nanomedicine properties simultaneously to improve tumor treatment. In the present study, imatinib mesylate (IMA) was used to normalize the tumor microenvironment including platelet-derived growth factor receptor-β expression inhibition, tumor vessel normalization, and tumor perfusion improvement as demonstrated by immunofluorescence staining. In addition, the effect of tumor microenvironment normalization on tumor delivery of nanomedici

SUBMITTER: Zhang B 

PROVIDER: S-EPMC5308750 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature