The missing link: Predicting connectomes from noisy and partially observed tract tracing data.

ABSTRACT: Our understanding of the wiring map of the brain, known as the connectome, has increased greatly in the last decade, mostly due to technological advancements in neuroimaging techniques and improvements in computational tools to interpret the vast amount of available data. Despite this, with the exception of the C. elegans roundworm, no definitive connectome has been established for any species. In order to obtain this, tracer studies are particularly appealing, as these have proven highly reliable. The downside of tract tracing is that it is costly to perform, and can only be applied ex vivo. In this paper, we suggest that instead of probing all possible connections, hitherto unknown connections may be predicted from the data that is already available. Our approach uses a 'latent space mod

SUBMITTER: Hinne M 

PROVIDER: S-EPMC5308841 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature