Benzimidazopurine nucleosides from N⁶-aryl adenosine derivatives by PhI(OAc)₂-mediated C-N bond formation, no metal needed.

ABSTRACT: The reaction of a variety of N⁶-aryl 2'-deoxyadenosine and adenosine derivatives with PhI(OAc)₂ in 1,1,1,3,3,3-hexafluoro-2-propanol provides a facile access to benzimidazopurine nucleoside analogues by metal-free C-N bond formation with a purinyl nitrogen atom. These reactions likely proceed via radical-cation/radical processes as indicated by radical inhibition experiments.

SUBMITTER: Satishkumar S 

PROVIDER: S-EPMC5309161 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature