Comparison of the discriminative stimulus and response rate effects of ^Δ9-tetrahydrocannabinol and synthetic cannabinoids in female and male rats.

ABSTRACT:

Background

Women report greater sensitivity to the subjective effects of Δ⁹-tetrahydrocannabinol (THC). Similarly, female rodents tend to be more sensitive to some pharmacological effects of THC and synthetic cannabinoids. This study examined sex differences in discriminative stimulus and response rate effects of THC and synthetic cannabinoids in rats.

Methods

A cumulative dosing THC discrimination procedure was utilized to evaluate sex differences in the discriminative stimulus effects of THC and three synthetic cannabinoids: CP47,497, WIN55,212-2, and JWH-018. Sex differences in the effects of these four compounds and a degradant of A-834735 on response rates also were assessed in a food-reinforced discrete dosing procedure.

Results

Females required a low

SUBMITTER: Wiley JL 

PROVIDER: S-EPMC5309167 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature