Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy.

ABSTRACT: Photodynamic therapy (PDT) is an established palliative treatment for perihilar cholangiocarcinoma that is clinically promising. However, tumors tend to regrow after PDT, which may result from the PDT-induced activation of survival pathways in sublethally afflicted tumor cells. In this study, tumor-comprising cells (i.e., vascular endothelial cells, macrophages, perihilar cholangiocarcinoma cells, and EGFR-overexpressing epidermoid cancer cells) were treated with the photosensitizer zinc phthalocyanine that was encapsulated in cationic liposomes (ZPCLs). The post-PDT survival pathways and metabolism were studied following sublethal (LC₅₀) and supralethal (LC₉₀) PDT. Sublethal PDT induced survival signaling in perihilar cholangiocarcinoma (SK-ChA-1) cells via mainly HI

SUBMITTER: Weijer R 

PROVIDER: S-EPMC5309296 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature