Mitochondrial mass and activity as a function of body composition in individuals with spinal cord injury.

ABSTRACT: Spinal cord injury (SCI) is accompanied by deterioration in body composition and severe muscle atrophy. These changes put individuals at risk for insulin resistance, type II diabetes, and cardiovascular disease. To determine the relationships between skeletal muscle mitochondrial mass, activity, and body composition, 22 men with motor complete SCI were studied. Body composition assessment was performed using dual-energy X-ray absorptiometry and magnetic resonance imaging. Skeletal muscle biopsies were obtained from the vastus lateralis muscle to measure citrate synthase (CS) and complex III (CIII) activity. CS activity was inversely related to %body fat (r = -0.57, P = 0.013), %leg fat (r = -0.52, P = 0.027), %trunk fat (r = -0.54, P = 0.020), and %android fat (r = -0.54, P = 0.017). CIII

SUBMITTER: O'Brien LC 

PROVIDER: S-EPMC5309572 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature