Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.

ABSTRACT: Cellular protein interaction networks are integral to host defence and immune signalling pathways, which are often hijacked by viruses via protein interactions. However, the comparative virus-host protein interaction networks and how these networks control host immunity and viral infection remain to be elucidated. Here, we mapped protein interactomes between human host and several influenza A viruses (IAV). Comparative analyses of the interactomes identified common and unique interaction patterns regulating innate immunity and viral infection. Functional screening of the 'core' interactome consisting of common interactions identified five novel host factors regulating viral infection. Plakophilin 2 (PKP2), an influenza PB1-interacting protein, restricts IAV replication and competes with PB

SUBMITTER: Wang L 

PROVIDER: S-EPMC5309701 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature