Clustering of 770,000 genomes reveals post-colonial population structure of North America.

ABSTRACT: Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within the network and annotate these clusters using a database of over 20 million genealogical records. Recent population patterns captured by IBD clustering include immigrants such as Scandinavians and French Canadians; groups with continental admixture such as Puerto Ricans; settlers such as the Amish and Appalachians who experienced geographic or cultural isolation; and broad historic

SUBMITTER: Han E 

PROVIDER: S-EPMC5309710 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature