Microenvironment-derived factors driving metastatic plasticity in melanoma.

ABSTRACT: Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum, and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is linked to phenotype switching, where the microenvironment induces switches between invasive/MITF^LO versus proliferative/MITF^HI states. Since MITF also induces pigmentation, we hypothesize that macrometastatic success should be favoured by microenvironments that induce a MITF^HI/differentiated/proliferative state. Zebrafish imaging demonstrates that after extravasation, melanoma cells become pigmented and enact a gene expression program of melanocyte differentiation. We screened for microenvironmental factors leading to phenotype switching, and find that EDN3 induces a state

SUBMITTER: Kim IS 

PROVIDER: S-EPMC5309794 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature