Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria.

ABSTRACT: Brucella abortus σ^E1 is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon, bab1_0223-bab1_0226, is among the most highly activated gene sets in the σ^E1 regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription of yehZYXW is activated by the general stress sigma factor σ^S in Enterobacteriaceae, which suggests a functional role for this transport system in bacterial stress re

SUBMITTER: Herrou J 

PROVIDER: S-EPMC5309909 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature