Laboratory Assessment of the Anticoagulant Activity of Direct Oral Anticoagulants: A Systematic Review.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) are the treatment of choice for most patients with atrial fibrillation and/or noncancer-associated venous thromboembolic disease. Although routine monitoring of these agents is not required, assessment of anticoagulant effect may be desirable in special situations. The objective of this review was to summarize systematically evidence regarding laboratory assessment of the anticoagulant effects of dabigatran, rivaroxaban, apixaban, and edoxaban.

Methods

PubMed, Embase, and Web of Science were searched for studies reporting relationships between drug levels and coagulation assay results.

Results

We identified 109 eligible studies: 35 for dabigatran, 50 for rivaroxaban, 11 for apixaban, and 13 for edoxaban. The performance of

SUBMITTER: Samuelson BT 

PROVIDER: S-EPMC5310120 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature