Validation of olfactory deficit as a biomarker of Alzheimer disease.

ABSTRACT:

Background

We evaluated smell identification as a biomarker for Alzheimer disease (AD) by assessing its utility in differentiating normal aging from an amnestic disorder and determining its predictive value for conversion from amnestic mild cognitive impairment (aMCI) to AD.

Methods

Cross-sectional study (AD = 262, aMCI = 110, controls = 194) measuring smell identification (University of Pennsylvania Smell Identification Test [UPSIT]) and cognitive status was performed, as well as longitudinal analysis of aMCI participants (n = 96) with at least 1 year follow-up (mean 477.6 ± 223.3 days), to determine conversion by National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria.

Results

Odor iden

SUBMITTER: Woodward MR 

PROVIDER: S-EPMC5310210 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature