Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation.

ABSTRACT: The programming of cell fate by transcription factors requires precise regulation of their time and level of expression. The LIM-homeodomain transcription factor Islet1 (Isl1) is involved in cell-fate specification of motor neurons, and it may play a similar role in the inner ear. In order to study its role in the regulation of vestibulo-motor development, we investigated a transgenic mouse expressing Isl1 under the Pax2 promoter control (Tg ^+/- ). The transgenic mice show altered level, time, and place of expression of Isl1 but are viable. However, Tg ^+/- mice exhibit hyperactivity, including circling behavior, and progressive age-related decline in hearing, which has been reported previously. Here, we describe the molecular and morphological changes in the cerebellu

SUBMITTER: Bohuslavova R 

PROVIDER: S-EPMC5310572 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature