Durable vesicles for reconstitution of membrane proteins in biotechnology.

ABSTRACT: The application of membrane proteins in biotechnology requires robust, durable reconstitution systems that enhance their stability and support their functionality in a range of working environments. Vesicular architectures are highly desirable to provide the compartmentalisation to utilise the functional transmembrane transport and signalling properties of membrane proteins. Proteoliposomes provide a native-like membrane environment to support membrane protein function, but can lack the required chemical and physical stability. Amphiphilic block copolymers can also self-assemble into polymersomes: tough vesicles with improved stability compared with liposomes. This review discusses the reconstitution of membrane proteins into polymersomes and the more recent development of hybrid vesicles,

SUBMITTER: Beales PA 

PROVIDER: S-EPMC5310719 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature