Risk of dementia from proton pump inhibitor use in Asian population: A nationwide cohort study in Taiwan.

ABSTRACT:

Introduction

Concerns have been raised regarding the potential association between proton pump inhibitor (PPI) use and dementia.

Objective

This study aimed to examine this association in an Asian population.

Methods

Patients initiating PPI therapy between January 1, 2000 and December 31, 2003 without a prior history of dementia were identified from Taiwan's National Health Insurance Research Database. The outcome of interest was all-cause dementia. Cox regression models were applied to estimate the hazard ratio (HR) of dementia. The cumulative PPI dosage stratified by quartiles of defined daily doses and adjusted for baseline disease risk score served as the primary variables compared against no PPI use.

Results

We analyzed the data of 15726 participants aged 4

SUBMITTER: Tai SY 

PROVIDER: S-EPMC5310771 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature