Helicobacter pylori CagA induced interleukin-8 secretion in gastric epithelial cells.

ABSTRACT:

Aim

Since, contradictory data have been reported about the effect of diverse variants of H. pylori virulence factors on IL-8 induction, we aimed to analyze the effect of this diversity on levels of IL-8 secretion in AGS cell line.

Background

Helicobacter pylori colonizes the human stomach and induces the activation of inflammatory cytokines, including interleukin (IL)-8, in the gastric mucosa. This induction promotes neutrophil and monocyte recruitment that causes gastric tissue damage.

Methods

To determine whether different strains of H. pylori and their CagA variants have possible roles on IL-8 induction, polarized AGS cell line was infected with CagA+ H. pylori strains carrying different EPIYA motifs (ABCCC and ABC) and CagA- strain for

SUBMITTER: Fazeli Z 

PROVIDER: S-EPMC5310799 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature