Dopamine-Related Disruption of Functional Topography of Striatal Connections in Unmedicated Patients With Schizophrenia.

ABSTRACT:

Importance

Despite the well-established role of striatal dopamine in psychosis, current views generally agree that cortical dysfunction is likely necessary for the emergence of psychotic symptoms. The topographic organization of striatal-cortical connections is central to gating and integration of higher-order information, so a disruption of such topography via dysregulated dopamine could lead to cortical dysfunction in schizophrenia. However, this hypothesis remains to be tested using multivariate methods ascertaining the global pattern of striatal connectivity and without the confounding effects of antidopaminergic medication.

Objectives

To examine whether the pattern of brain connectivity across striatal subregions is abnormal in unmedicated patients with schizophrenia an

SUBMITTER: Horga G 

PROVIDER: S-EPMC5310843 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature