Spatial gender-age-period-cohort analysis of pancreatic cancer mortality in Spain (1990-2013).

ABSTRACT: Recently, the interest in studying pancreatic cancer mortality has increased due to its high lethality. In this work a detailed analysis of pancreatic cancer mortality in Spanish provinces was performed using recent data. A set of multivariate spatial gender-age-period-cohort models was considered to look for potential candidates to analyze pancreatic cancer mortality rates. The selected model combines features of APC (age-period-cohort) models with disease mapping approaches. To ensure model identifiability sum-to-zero constraints were applied. A fully Bayesian approach based on integrated nested Laplace approximations (INLA) was considered for model fitting and inference. Sensitivity analyses were also conducted. In general, estimated average rates by age, cohort, and period are higher i

SUBMITTER: Etxeberria J 

PROVIDER: S-EPMC5310874 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature