Coagulation profile in patients undergoing video-assisted thoracoscopic lobectomy: A randomized, controlled trial.

ABSTRACT:

Background

Knowledge about the impact of Low-Molecular-Weight Heparin (LMWH) on the coagulation system in patients undergoing minimal invasive lung cancer surgery is sparse. The aim of this study was to assess the effect of LMWH on the coagulation system in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS) lobectomy for primary lung cancer.

Methods

Sixty-three patients diagnosed with primary lung cancer undergoing VATS lobectomy were randomized to either subcutaneous injection with dalteparin (Fragmin®) 5000 IE once daily or no intervention. Coagulation was assessed pre-, peri-, and the first two days postoperatively by standard coagulation blood test, thromboelastometry (ROTEM®) and thrombin generation.

Results

Patients undergoing potential curative sur

SUBMITTER: Christensen TD 

PROVIDER: S-EPMC5310875 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature