Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles.

ABSTRACT: Avian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the I

SUBMITTER: Okino CH 

PROVIDER: S-EPMC5310907 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature