A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis.

ABSTRACT: Cryptosporidiosis has emerged as a leading cause of non-viral diarrhea in children under five years of age in the developing world, yet the current standard of care to treat Cryptosporidium infections, nitazoxanide, demonstrates limited and immune-dependent efficacy. Given the lack of treatments with universal efficacy, drug discovery efforts against cryptosporidiosis are necessary to find therapeutics more efficacious than the standard of care. To date, cryptosporidiosis drug discovery efforts have been limited to a few targeted mechanisms in the parasite and whole cell phenotypic screens against small, focused collections of compounds. Using a previous screen as a basis, we initiated the largest known drug discovery effort to identify novel anticryptosporidial agents. A high-content imag

SUBMITTER: Love MS 

PROVIDER: S-EPMC5310922 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature