Relation of Dysglycemia to Structural Brain Changes in a Multiethnic Elderly Cohort.

ABSTRACT:

Objectives

Abnormally high glucose levels (dysglycemia) increase with age. Epidemiological studies suggest that dysglycemia is a risk factor for cognitive impairment but the underlying pathophysiological mechanisms remain unclear. The objective of this study was to examine the relation of dysglycemia clinical categories (normal glucose tolerance (NGT), pre-diabetes, undiagnosed diabetes, known diabetes) with brain structure in older adults. We also assessed the relation between dysglycemia and cognitive performance.

Design

Cross-sectional and longitudinal cohort study.

Setting

Northern Manhattan (Washington Heights, Hamilton Heights, and Inwood).

Participants

Medicare recipients 65 years and older.

Measurements

Dysglycemia categories were based on HBA1c

SUBMITTER: Reitz C 

PROVIDER: S-EPMC5311018 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature