Targeting Angiotensin II Type-1 Receptor (AT₁R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8⁺ T Cells during Blood-Stage Malaria.

ABSTRACT: CD8⁺ T-cell response is critical in the pathogenesis of cerebral malaria during blood-stage. Our group and other have been shown that angiotensin II (Ang II) and its receptor AT₁ (AT₁R), a key effector axis of renin-angiotensin system (RAS), have immune regulatory effects on T cells. Previously, we showed that inhibition of AT₁R signaling protects mice against the lethal disease induced by Plasmodium berghei ANKA infection However, most of the Ang II/AT₁R actions were characterized by using only pharmacological approaches, the effects of which may not always be due to a specific receptor blockade. In addition, the mechanisms of action of the AT₁R in inducing the pathogenic activity of Plasmodium-specific CD8

SUBMITTER: Silva-Filho JL 

PROVIDER: S-EPMC5311040 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature