Evolution of Anabaenopeptin Peptide Structural Variability in the Cyanobacterium <i>Planktothrix</i>.

ABSTRACT: Cyanobacteria are frequently involved in the formation of harmful algal blooms wherein, apart from the toxic microcystins, other groups of bioactive peptides are abundant as well, such as anabaenopeptins (APs). The APs are synthesized nonribosomally as cyclic hexapeptides with various amino acids at the exocyclic position. We investigated the presence and recombination of the AP synthesis gene cluster (apnA-E) through comparing 125 strains of the bloom-forming cyanobacterium Planktothrix spp., which were isolated from numerous shallow and deep water habitats in the temperate and tropical climatic zone. Ten ecologically divergent strains were purified and genome sequenced to compare their entire apnA-E gene cluster. In order to quantify apn gene distribution patt

SUBMITTER: Entfellner E 

PROVIDER: S-EPMC5311044 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature