A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N¹-methyladenosine modification.

ABSTRACT: Introns are found in 5' untranslated regions (5'UTRs) for 35% of all human transcripts. These 5'UTR introns are not randomly distributed: Genes that encode secreted, membrane-bound and mitochondrial proteins are less likely to have them. Curiously, transcripts lacking 5'UTR introns tend to harbor specific RNA sequence elements in their early coding regions. To model and understand the connection between coding-region sequence and 5'UTR intron status, we developed a classifier that can predict 5'UTR intron status with >80% accuracy using only sequence features in the early coding region. Thus, the classifier identifies transcripts with 5' proximal-intron-minus-like-coding regions ("5IM" transcripts). Unexpectedly, we found that the early coding sequence features definin

SUBMITTER: Cenik C 

PROVIDER: S-EPMC5311483 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature