Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease.

ABSTRACT: Coronary artery disease (CAD) is the most prevalent cause of mortality and morbidity worldwide and the number of individuals at risk is increasing. To better manage cardiovascular diseases, improved tools for risk prediction including the identification of novel accurate biomarkers are needed. MicroRNA (miRNA) are essential post-transcriptional modulators of gene expression leading to mRNA suppression or translational repression. Specific expression profiles of circulating miRNA have emerged as potential noninvasive diagnostic biomarkers of diseases. The aim of this study was to identify the potential diagnostic value of circulating miRNA with CAD. Circulating miR-145, miR-155, miR-92a and let-7c were selected and validated by quantitative PCR in 69 patients with CAD and 30 control subject

SUBMITTER: Faccini J 

PROVIDER: S-EPMC5311865 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature