A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.

ABSTRACT: Combination therapies targeting multiple recovery mechanisms have the potential for additive or synergistic effects, but experimental design and analyses of multimodal therapeutic trials are challenging. To address this problem, we developed a data-driven approach to integrate and analyze raw source data from separate pre-clinical studies and evaluated interactions between four treatments following traumatic brain injury. Histologic and behavioral outcomes were measured in 202 rats treated with combinations of an anti-inflammatory agent (minocycline), a neurotrophic agent (LM11A-31), and physical therapy consisting of assisted exercise with or without botulinum toxin-induced limb constraint. Data was curated and analyzed in a linked workflow involving non-linear principal component analysi

SUBMITTER: Haefeli J 

PROVIDER: S-EPMC5311970 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature