Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB.

ABSTRACT: Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process. Several drugs have already been successfully repurposed for other clinical conditions including drug resistant tuberculosis (DR-TB). Though TB can be cured completely with the use of currently available anti-tubercular drugs, emergence of drug resistant strains of Mycobacterium tuberculosis and the huge death toll globally, together necessitate urgently newer and effective drugs for TB. Therefore, we performed virtual screening of 1554 FDA approved drugs against murE, which is essential for peptidoglycan biosynthesis of M. tuberculosis. We used Glide and AutoDock Vin

SUBMITTER: Brindha S 

PROVIDER: S-EPMC5312000 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature