Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder.

ABSTRACT: Major depressive disorder (MDD) is predicted to be the second leading cause of global disease burden by 2030. A large number of MDD patients do not respond to the currently available medication because of its poorly understood etiology. Recently, studies of microRNAs (miRNAs), which act as a molecular switch of gene expression, have shown promise in identifying a molecular network that could provide significant clues to various psychiatric illnesses. Using an in vitro system, a rodent depression model, and a human postmortem brain, we investigated the role of a brain-enriched, neuron-specific miRNA, miR-124-3p, whose expression is highly dysregulated in stressed rodents, and identified a set of target genes involved in stress response and neural plasticity. We also found that miR-124-3p is

SUBMITTER: Roy B 

PROVIDER: S-EPMC5312059 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature