Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia.

ABSTRACT: Relapse in pediatric T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem and is thought to be associated with clonal selection during treatment. In this study we used an established pre-clinical model of induction therapy to increase our understanding of the effect of engraftment and chemotherapy on clonal selection and acquisition of drug resistance in vivo. Immune-deficient mice were engrafted with patient diagnostic specimens and exposed to a repeated combination therapy consisting of vincristine, dexamethasone, L-asparaginase and daunorubicin. Any re-emergence of disease following therapy was shown to be associated with resistance to dexamethasone, no resistance was observed to the other three drugs. Immunoglobulin/T-cell receptor gene rearrangements clos

SUBMITTER: Yadav BD 

PROVIDER: S-EPMC5312271 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature