High expression of cholesterol biosynthesis genes is associated with resistance to statin treatment and inferior survival in breast cancer.

ABSTRACT: There is sufficient evidence that statins have a protective role against breast cancer proliferation and recurrence, but treatment predictive biomarkers are lacking. Breast cancer cell lines displaying diverse sensitivity to atorvastatin were subjected to global transcriptional profiling and genes significantly altered by statin treatment were identified. Atorvastatin treatment strongly inhibited proliferation in estrogen receptor (ER) negative cell lines and a commensurate response was also evident on the genome-wide transcriptional scale, with ER negative cells displaying a robust deregulation of genes involved in the regulation of cell cycle progression and apoptosis. Interestingly, atorvastatin upregulated genes involved in the cholesterol biosynthesis pathway in all cell lines, irresp

SUBMITTER: Kimbung S 

PROVIDER: S-EPMC5312337 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature