Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway.

ABSTRACT: Breast cancer is one of the most widespread carcinoma and one of the main causes of cancer-related death worldwide, especially in women aged between 35 and 75 years. Among the different subtypes, triple negative breast cancer (TNBC) is characterized by the total absence of the estrogen-receptor (ER) and progesteron-receptor (PR) expression as well as the lack of human epidermal growth factor receptor 2 (HER2) overexpression or gene amplification. These biological characteristics confer to TNBC a higher aggressiveness and relapse risk along with poorer prognosis compared to other subtypes. Indeed, 5-years survival rate is still low and almost all patients die, despite any adjuvant treatment which at moment represents the heading pharmacological approach. To date, several clinical trials hav

SUBMITTER: Massihnia D 

PROVIDER: S-EPMC5312414 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature