A meta-analysis reveals complex regulatory properties at Taf14-repressed genes.

ABSTRACT:

Background

Regulation of gene transcription in response to stress is central to a cell's ability to cope with environmental challenges. Taf14 is a YEATS domain protein in S.cerevisiae that physically associates with several transcriptionally relevant multisubunit complexes including the general transcription factors TFIID and TFIIF and the chromatin-modifying complexes SWI/SNF, INO80, RSC and NuA3. TAF14 deletion strains are sensitive to a variety of stresses suggesting that it plays a role in the transcriptional stress response.

Results

In this report we survey published genome-wide transcriptome and occupancy data to define regulatory properties associated with Taf14-dependent genes. Our transcriptome analysis reveals that stress related, TATA-containing and SAGA-dependent

SUBMITTER: Nemet J 

PROVIDER: S-EPMC5312515 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature