Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology.

ABSTRACT:

Background

Comparative transcriptomics can answer many questions in developmental and evolutionary developmental biology. Most transcriptomic studies start by showing global patterns of variation in transcriptomes that differ between species or organs through developmental time. However, little is known about the kinds of expression differences that shape these patterns.

Results

We compared transcriptomes during the development of two morphologically distinct serial organs, the upper and lower first molars of the mouse. We found that these two types of teeth largely share the same gene expression dynamics but that three major transcriptomic signatures distinguish them, all of which are shaped by differences in the relative abundance of different cell types. First, lower/uppe

SUBMITTER: Pantalacci S 

PROVIDER: S-EPMC5312534 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature