Differential regulation of riboflavin supply genes in Vibrio cholerae.

ABSTRACT:

Background

Riboflavin is the precursor of important redox cofactors such as flavin mononucleotide (FMN) and flavin adenine dinucleotide, required for several biological processes. Vibrio cholerae, a pathogenic bacterium responsible for the cholera disease, possesses the ability to biosynthesize de novo as well as to uptake riboflavin through the riboflavin biosynthetic pathway (RBP) and the RibN importer, respectively. The intra-organism relationship between riboflavin biosynthesis and uptake functions has not been studied.

Results

This work determined the transcriptional organization of RBP genes and ribN in V. cholerae through reverse transcription polymerase chain reaction and analyzed their expression when growing with or without extracellular ribofl

SUBMITTER: Cisternas IS 

PROVIDER: S-EPMC5312566 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature