Computational Approaches for Revealing the Structure of Membrane Transporters: Case Study on Bilitranslocase.

ABSTRACT: The structural and functional details of transmembrane proteins are vastly underexplored, mostly due to experimental difficulties regarding their solubility and stability. Currently, the majority of transmembrane protein structures are still unknown and this present a huge experimental and computational challenge. Nowadays, thanks to X-ray crystallography or NMR spectroscopy over 3000 structures of membrane proteins have been solved, among them only a few hundred unique ones. Due to the vast biological and pharmaceutical interest in the elucidation of the structure and the functional mechanisms of transmembrane proteins, several computational methods have been developed to overcome the experimental gap. If combined with experimental data the computational information enables rapid, low cos

SUBMITTER: Venko K 

PROVIDER: S-EPMC5312651 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature